The extensive construction work on the hospital premises during the 1930s (06-768) was to continue after the war within the framework of the so-called Two-year plan according to the state planning and statistic authorities. The existing pavilions were to be expanded by a large new building containing operating departments (surgical, gynaecological with maternity ward, and otolaryngology department) and a paediatric ward. The design project, from which the otolaryngology department was eventually omitted, was carried out between 1949 and 1951 by accomplished Prague specialists in hospital buildings František Čermák and Gustav Paul, both of whom had previously written several treatises on the subject. (Čermák with Paul had designed the first – expansive – project for the reconstruction and completion of the hospital premises in a purely Functionalist style in 1947; it was not carried out, most probably due to its substantial technical and financial complications.)
The new monobloc, situated in the southern part of the grounds and parallel to the internal medicine pavilion (06-768), is comprised of two sections whose layouts are shifted in relation to each other. The more extensive operating section was placed towards the north and was made up of a longitudinal section and two perpendicular wings facing the access road and forming a small entrance courtyard. Further to the south, the architects placed the paediatric ward which, in spite of being connected to main building through a ground-floor corridor, features its own entrance. The architects laid out the busy inner roads so that they lead from the main hospital entry road towards the individual sections of the monobloc from the north. Thus, the front, southern section containing the patient wards, with its architecturally distinctive paediatric tract with continuous balconies on both floors, was quiet and protected from the noise and traffic of the entrance gate.
Although Čermák and Paul's work typically has its roots in Functionalism, as evidenced by the afore-mentioned 1947 design, the design that was actually carried out is of more traditional appearance, mainly thanks to the building's pitched roof. However, several Modernist features were implemented on the facade (notably the wide range of windows sizes and sporadically placed corner and projecting windows), despite the existing diktat of the one officially recognized artistic trend – Socialist Realism. The architects applied a similarly formal solution to the contemporary building of the hospital in Chrudim (1950-1957).
During the following decades, the hospital premises underwent construction modifications, with the addition, in 1979, of a sculpture by František Janda in the entrance “courtyard” entitled Boj člověka s přírodou (Man's Battle with Nature). The monobloc underwent significant changes in the years between 2002 and 2004 when it was the subject of reconstruction work based on designs by the studio Architektonická kancelář Burian – Křivinka; the project itself was carried out by the Prague office of AND, architektonický ateliér. Most of the changes concerned the interiors, with all departments being modernized and the hitherto vacant attic space made habitable. The designers added a cafeteria and a glazed first-floor corridor to the entrance frontage of the monobloc.